Apr 22, 2026·Formal Sciences·260423.0002
Closing the Domain Gap in Biomedical Imaging by In-Context Control Samples
Ana Sanchez-Fernandez, Thomas Pinetz, Werner Zellinger, Günter Klambauer
This paper proposes CS-ARM-BN, a meta-learning method that uses negative control samples to adapt deep learning models to new experimental batches in biomedical imaging, closing the domain gap caused by batch effects. The approach achieves 0.935±0.018 accuracy on drug mechanism-of-action classification, recovering performance from 0.862±0.060 back to near training-domain levels of 0.939±0.005.